What is it about?
The aim of the present study was to evaluate the bioavailability of diclofenac in the skin at longer time intervals after diclofenac application using different application modalities. Therefore, three different forms of diclofenac application (passive, occlusive, iontophoretic) were examined in order to detect the anti-inflammatory effect and thereby get a better understanding of the skin-penetrating and reservoir-building behaviour of diclofenac.
Featured Image
Why is it important?
There is scarce information concerning the pharmacodynamic behaviour of topical substances used in the physiotherapy setting. The aim of the present study was to estimate the formation and emptying of the diclofenac skin reservoir after passive, semiocclusive, and electrically assisted applications of diclofenac.
Perspectives
The results of this study indicated that the formation and emptying of a diclofenac skin reservoir were found to be dependent on the diclofenac application mode. Penetration enhanced delivery resulted in a faster emptying of the reservoir. Our results assume that the application with the fastest reservoir building up conditions may result in a greater delivery of active substances to the viable tissues, increasing the effectiveness of the physiotherapeutic treatment.
Dr Ron Clijsen
SUPSI
Read the Original
This page is a summary of: In vivo determination of the diclofenac skin reservoir: comparison between passive, occlusive, and iontophoretic application, Drug Design Development and Therapy, February 2015, Taylor & Francis,
DOI: 10.2147/dddt.s76002.
You can read the full text:
Contributors
The following have contributed to this page
