What is it about?
Health professionals that have to deal with Prostate Cancer patients under hormonal therapy (is not uncommon to see treatments along 5 to 10 years) should know that intermittent therapy is a feasible option in patients without signs of cancer progression. Intermittent, means stopping the continuous treatment several months (e.g. 6 to 20 months in average) until the first sign of cancer progression. This off period could be repeated several times.
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Why is it important?
Compared to continuous therapy, intermittent therapy has not shown significant differences in overall survival at least after more than 20 years of experience using it and big trials with 9 years of follow up. Conversely, several advantages could be reached: · Better quality of life of patients thanks to off periods · Less likelihood of adverse effects due to lower exposition to medication · Delayed onset of resistance to hormonal treatment (still to be proved) · Significantly lower costs for the Public Health System
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This page is a summary of: Intermittent androgen deprivation therapy: recommendations to improve the management of patients with prostate cancer following the GRADE approach, Cancer Management and Research, August 2018, Dove Medical Press,
DOI: 10.2147/cmar.s164856.
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