Antiestrogens may be effective only by the upregulation of estrogen signaling
What is it about?
Antiestrogen compounds were developed against breast cancer based on the erroneous concept that increased estrogen signaling is a promoter of DNA-damage, genome instability and tumor growth.
Why is it important?
Whatever type of available endocrine therapies may be used, including estrogen, antiestrogen treatment or oophorectomy, an extreme upregulation of estrogen signaling may lead to successful prevention and treatment for breast cancer. De novo or acquired "antiestrogen resistance" of tumors may be attributed to the defective or later exhausted genetic capacity of patients for the extreme upregulation of estrogen receptor expression and aromatase synthesis.
The following have contributed to this page: professor Zsuzsanna Suba