Hemodynamic Parameters in Patients Undergoing TURP and TURBT Due to Additive Intrathecal Clonidine

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Hemodynamic Parameters in Patients Undergoing TURP and TURBT Due to Additive Intrathecal Clonidine

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Introduction: Clonidine has been used by anesthesiologists as an anesthetic adjunct to provide increased perioperative cardiovascular and sympathoadrenal stability, to enhance general and regional anesthesia, as well as sedation and analgesia. Materials and Method: This randomized prospective double blind study conducted at MIOT hospitals, Chennai, from October 2014 – December 2015, evaluated the effective dose of clonidine with 10 mg of 0.5% heavy bupivacaine in 80 patients posted for these surgeries and also to find the effect of various doses of clonidine on various subarachnoid block characteristics. Patients of either physical status ASA 1 or ASA 2 admitted for elective TURP and TURBT. Results: There were statistically significant differences in the heart rate between the groups from 30 min onwards but none of the patients in any group needed atropine to treat bradycardia (ie., heart rate did not fall below 60 beats per minute). There was a significant fall in MAP (mean arterial pressure) at 10-20 minutes in all the 4 groups following the subarachnoid block. The mean dose of ephedrine given was 10 mg in group NS, 10 mg in group BC25, 15 mg in group BC35 which was significant. Conclusion: Addition of 35 mcg of clonidine to bupivacaine when compared to 25 mcg/15 mcg clonidine significantly prolongs the duration of analgesia without affecting the onset and maximum level achieved of sensory block.

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