What is it about?
A Comparative Study of Mixture of Clonidine - Fentanyl Compared to Clonidine Alone as an Adjuvant
Featured Image
Photo by Abigail on Unsplash
Why is it important?
Aims: Use of adjuvant drug along with inj. Bupivacaine for spinal anaesthesia is a well know modality & is being practiced to increase duration of anaesthesia & postoperative analgesia. The present study is carried out to study Clonidine + Fentanyl vs. only Clonidine when used as adjuvant to Bupivacaine increases the duration of spinal analgesia. Also the study was conducted to note the side effects of the adjuvant drugs when used for spinal anaesthesia Methods: It was a prospective, randomized, double-blind study, 60 ASA grade I-II patients (30 in each group), who were scheduled for elective infra-umbilical surgery under spinal anesthesia were recruited. Group- M patients received hyperbaric Bupivacaine (2.5ml) + Clonidine 30μg for spinal anaesthesia. Group- C patients received Bupivacaine (0.5%) 2.5ml + fentanyl (15μg) + Clonidine (15μg). The total volume of intra-thecal drug along with adjuvant drugs was constant (i.e. 3 ml, by adding normal saline) in both the groups. Onset and duration of sensory, motor block, effective analgesia, hemodynamic profile, post-operative pain score and side effects if any were recorded. Results: Duration of analgesia and duration of sensory and motor block were significantly longer in Group- C (165.02 ± 12.72 min) as compared to Group- M (130.78 ± 5.95 min). Haemodynamic profile showed significant low HR and MAP at certain time intervals in the GroupM as compared to Group- C. Patients of Group- M showed a significantly (p < 0.05) higher level of VAS as compared to Group- C at 60 min, 90 min and 120 min interval time. Conclusion: Low dose of Clonidine (15mcg) + Fentanyl (15mcg) as an adjuvant to intra-thecal %0.5 Bupivacaine for spinal anaesthesia produced prolonged post-operative analgesia in patients undergoing infra-umbilical surgeries with stable haemodynmics.
Perspectives
Aims: Use of adjuvant drug along with inj. Bupivacaine for spinal anaesthesia is a well know modality & is being practiced to increase duration of anaesthesia & postoperative analgesia. The present study is carried out to study Clonidine + Fentanyl vs. only Clonidine when used as adjuvant to Bupivacaine increases the duration of spinal analgesia. Also the study was conducted to note the side effects of the adjuvant drugs when used for spinal anaesthesia Methods: It was a prospective, randomized, double-blind study, 60 ASA grade I-II patients (30 in each group), who were scheduled for elective infra-umbilical surgery under spinal anesthesia were recruited. Group- M patients received hyperbaric Bupivacaine (2.5ml) + Clonidine 30μg for spinal anaesthesia. Group- C patients received Bupivacaine (0.5%) 2.5ml + fentanyl (15μg) + Clonidine (15μg). The total volume of intra-thecal drug along with adjuvant drugs was constant (i.e. 3 ml, by adding normal saline) in both the groups. Onset and duration of sensory, motor block, effective analgesia, hemodynamic profile, post-operative pain score and side effects if any were recorded. Results: Duration of analgesia and duration of sensory and motor block were significantly longer in Group- C (165.02 ± 12.72 min) as compared to Group- M (130.78 ± 5.95 min). Haemodynamic profile showed significant low HR and MAP at certain time intervals in the GroupM as compared to Group- C. Patients of Group- M showed a significantly (p < 0.05) higher level of VAS as compared to Group- C at 60 min, 90 min and 120 min interval time. Conclusion: Low dose of Clonidine (15mcg) + Fentanyl (15mcg) as an adjuvant to intra-thecal %0.5 Bupivacaine for spinal anaesthesia produced prolonged post-operative analgesia in patients undergoing infra-umbilical surgeries with stable haemodynmics.
Red Flower Publication Publications
Red Flower Publication Pvt Ltd
Read the Original
This page is a summary of: A Comparative Study of Mixture of Clonidine - Fentanyl Compared to Clonidine Alone as an Adjuvant to Intrathecal Hyperbaric Bupivacaine Under Spinal Anaesthesia for Infraumbilical Surgeries, Indian Journal of Anaesthesia and Analgesia, June 2020, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.7320.21.
You can read the full text:
Contributors
The following have contributed to this page
