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Evaluation Safety and Efficacy of Chloroprocaine V/S Chloroprocaine With 20μg Fentanyl
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Aims: To Investigate the efficacy and safety profile of the Fentanyl when added to Chloroprocaine for outpatient spinal anaesthesia in terms of quality and duration of sensory and motor blockade and effective analgesia. Settings and Design: prospective, randomized, double blind study Methods and Material: After institutional review board approval and informed written consent from patients,100 participants, aged 18 to 60 years, of ASA Physical status I, II or III scheduled for lower limb ambulatory surgery under subarachnoid block, were randomly divided into two groups (n = 50 each); Group C received 4.0ml (40 mg) 1% isobaric Chloroprocaine + 0.4ml Normal Saline (0.9%) and Group F received 4.0ml (40mg) 1% isobaric Chloroprocaine + 0.4ml Fentanyl (20μg). Degree of sensory and motor block, postoperative analgesia (VAS score), time of 1st rescue analgesia (effective analgesia), time of ambulation, voiding of spontaneous urine, hemodynamic variables and side effects were evaluated and compared. At VAS ≥ 4, rescue analgesic Inj. Diclofenac Sodium I.V. was given. Results: Participants in Group F had prolonged onset (3.91 ± 1.09 min), peak (7.54 ± 1.30 min) and duration (110.74 ± 9.78 min) of sensory block than group C (3.02 ± 0.97 min), (6.53 ± 1.34 min), (104.64 ± 10.83 min) respectively. Motor characteristics were comparable in both groups with onset, peak and duration respectively in group C was (4.01 ± 1.42 min),(7.48 ± 1.89 min) and(79.6 ± 8.42 min) and in group F was (4.52 ± 0.83 min), (9.05 ± 0.52 min),(90.76 ± 5.59 min). Duration of analgesia was longer in Group F (148.36 ± 2.84 min) than in Group C (145.12 ± 2.78 min). Time of ambulation was early in group C (110.62 ± 5.25) than group F (115.42 ± 5.8 9min). Voiding of spontaneous urine was early in group C (112.8 ± 4.69) than group F (115.76 ± 5.92 min). Incidence of side effects was comparable in both groups.
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Aims: To Investigate the efficacy and safety profile of the Fentanyl when added to Chloroprocaine for outpatient spinal anaesthesia in terms of quality and duration of sensory and motor blockade and effective analgesia. Settings and Design: prospective, randomized, double blind study Methods and Material: After institutional review board approval and informed written consent from patients,100 participants, aged 18 to 60 years, of ASA Physical status I, II or III scheduled for lower limb ambulatory surgery under subarachnoid block, were randomly divided into two groups (n = 50 each); Group C received 4.0ml (40 mg) 1% isobaric Chloroprocaine + 0.4ml Normal Saline (0.9%) and Group F received 4.0ml (40mg) 1% isobaric Chloroprocaine + 0.4ml Fentanyl (20μg). Degree of sensory and motor block, postoperative analgesia (VAS score), time of 1st rescue analgesia (effective analgesia), time of ambulation, voiding of spontaneous urine, hemodynamic variables and side effects were evaluated and compared. At VAS ≥ 4, rescue analgesic Inj. Diclofenac Sodium I.V. was given. Results: Participants in Group F had prolonged onset (3.91 ± 1.09 min), peak (7.54 ± 1.30 min) and duration (110.74 ± 9.78 min) of sensory block than group C (3.02 ± 0.97 min), (6.53 ± 1.34 min), (104.64 ± 10.83 min) respectively. Motor characteristics were comparable in both groups with onset, peak and duration respectively in group C was (4.01 ± 1.42 min),(7.48 ± 1.89 min) and(79.6 ± 8.42 min) and in group F was (4.52 ± 0.83 min), (9.05 ± 0.52 min),(90.76 ± 5.59 min). Duration of analgesia was longer in Group F (148.36 ± 2.84 min) than in Group C (145.12 ± 2.78 min). Time of ambulation was early in group C (110.62 ± 5.25) than group F (115.42 ± 5.8 9min). Voiding of spontaneous urine was early in group C (112.8 ± 4.69) than group F (115.76 ± 5.92 min). Incidence of side effects was comparable in both groups.
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This page is a summary of: Evaluation Safety and Efficacy of Chloroprocaine V/S Chloroprocaine With 20μg Fentanyl in Subarachnoid Block in Participants Undergoing Lower Limb Ambulatory Surgery, Indian Journal of Anaesthesia and Analgesia, June 2020, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.7320.13.
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