Comparison of Effects of Fentanyl and Intravenous Paracetamol on Consumption of Sevoflurane

What is it about?

Comparison of Effects of Fentanyl and Intravenous Paracetamol on Consumption of Sevoflurane

Featured Image

Photo by Etienne Girardet on Unsplash

Photo by Etienne Girardet on Unsplash

Why is it important?

Aims: The study was designed to compare the effect of IVFentanyl vs. IV Paracetamol on consumption of Sevoflurane and the recovery characteristics. Plan of study: Patients scheduled for elective surgeries under general Anaesthesia are randomly allocated with 50 patients in each group. Group- F received Fentanyl 1mcg/kg per min as bolus 5min before infusion immediately after intubation. Group- P received Paracetamol 1gm in 100ml for a period of 15min and twenty five minutes before intubation. Intra-operatively Sevoflurane concentration was titrated to maintain entropy value of 40-60. Total volume of Sevoflurane consumed is obtained from GE/Datex-Omeda S/5 advance monitor and average Sevoflurane consumed in ml/hr is calculated. Results: Consumption of Sevoflurane in Group- F was 16.01 ± 0.95ml/hr as compared to 16.9 ± 2.2 ml/hr in Group- P which was statistically significant. Post extubation at the end of fifth minute all patients in Group- P attained score of 12 as compared to only 56% patients of Group- F and it was is statistica lly significant (p <0.001). Conclusion: Consumption of Sevoflurane & post-operative pain was less in Fentanyl group when compared to paracetamol group. However recovery characteristics are better in paracetamol group.

Perspectives