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Comparison of Conventional Dose versus Low-dose Infusion of Dexmedetomidine on Hemodynamic Stress

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Background: Laparoscopic cholecystectomy is one of the most common practiced surgeries for gall bladder disease. Dexmedetomidine is a α2 agonist with sedative, sympatholytic and analgesic properties and hence, it can be a very useful adjuvant in anaesthesia as stress response buster, sedative and analgesic. Materials and Methods: The present study was conducted on 90 patients with American Society of Anesthesiologists physical status I to III scheduled for laparoscopic cholecystectomy of both genders. Patients were divided into 3 Group. Group I (Control) patients received normal saline 0.9% infusion, Group II patients received dexmedetomidine infusion 1 mcg/kg/h and Group III patients received dexmedetomidine infusion 0.4 mcg/kg/h. parameters such as duration of anesthesia, duration of surgery, change in heart rate, MAP etc. was compared in both groups. Results: ASA I was 25 in Group I, 26 in Group II and 23 in Group III, ASA Grade II was 5 in Group I, 4 in Group II and 7 in Group III. The difference was nonsignificant (p > 0.05). Mean duration of anesthesia in Group I was 92.1 minute, in Group II was 98.4 minutes and in Group III was 85.2 minutes, mean duration of surgery in Group I was 77.4 minutes, in Group II was 92.3 minutes and in Group III was 75.1 minutes. The difference was nonsignificant (p > 0.05). The mean PR (beats/min) before starting in Group I was 88.3, in Group II was 91.4 and in Group III was 90.3. After 15 minutes was 87.2 in Group I, 82.3 in Group II and 80.4 in Group III. 1 minute after induction was 87.3, 82.5 and 80.6 in groups. MAP before staring was 99.3 mm Hg, 99.2 and 101.4 mm Hg in all groups, after 15 minutes was 98.4, 95.2 and 98.9 in all groups, 1 minute after induction was 98.2, 89.5 and 89.9 in all groups respectively. The difference was nonsignificant (p > 0.05). Conclusion: Low dose dexmedetomidine infusion in the dose of 0.4 mcg/kg/h effectively attenuates haemodynamic stress response without any adverse events.

Perspectives

Background: Laparoscopic cholecystectomy is one of the most common practiced surgeries for gall bladder disease. Dexmedetomidine is a α2 agonist with sedative, sympatholytic and analgesic properties and hence, it can be a very useful adjuvant in anaesthesia as stress response buster, sedative and analgesic. Materials and Methods: The present study was conducted on 90 patients with American Society of Anesthesiologists physical status I to III scheduled for laparoscopic cholecystectomy of both genders. Patients were divided into 3 Group. Group I (Control) patients received normal saline 0.9% infusion, Group II patients received dexmedetomidine infusion 1 mcg/kg/h and Group III patients received dexmedetomidine infusion 0.4 mcg/kg/h. parameters such as duration of anesthesia, duration of surgery, change in heart rate, MAP etc. was compared in both groups. Results: ASA I was 25 in Group I, 26 in Group II and 23 in Group III, ASA Grade II was 5 in Group I, 4 in Group II and 7 in Group III. The difference was nonsignificant (p > 0.05). Mean duration of anesthesia in Group I was 92.1 minute, in Group II was 98.4 minutes and in Group III was 85.2 minutes, mean duration of surgery in Group I was 77.4 minutes, in Group II was 92.3 minutes and in Group III was 75.1 minutes. The difference was nonsignificant (p > 0.05). The mean PR (beats/min) before starting in Group I was 88.3, in Group II was 91.4 and in Group III was 90.3. After 15 minutes was 87.2 in Group I, 82.3 in Group II and 80.4 in Group III. 1 minute after induction was 87.3, 82.5 and 80.6 in groups. MAP before staring was 99.3 mm Hg, 99.2 and 101.4 mm Hg in all groups, after 15 minutes was 98.4, 95.2 and 98.9 in all groups, 1 minute after induction was 98.2, 89.5 and 89.9 in all groups respectively. The difference was nonsignificant (p > 0.05). Conclusion: Low dose dexmedetomidine infusion in the dose of 0.4 mcg/kg/h effectively attenuates haemodynamic stress response without any adverse events.

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This page is a summary of: Comparison of Conventional Dose versus Low-dose Infusion of Dexmedetomidine on Hemodynamic Stress Response: A Prospective Institutional Based Study, Indian Journal of Anaesthesia and Analgesia, April 2020, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.7220.26.
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