Comparison of Effects of Oral Ivabradine and Oral Clonidine as Premedicants on Intraocular Pressure

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Comparison of Effects of Oral Ivabradine and Oral Clonidine as Premedicants on Intraocular Pressure

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Background: Endotracheal intubation done with succinylcholine raises intraocular pressure which can be of significance in cases of traumatic open globe injury. Aims: The study was done to compare the efficacy of oral Ivabradine and Clonidine in lowering the intraocular pressure rise following intubation using succinylcholine. Methods: A total of 105 patients were enrolled. Three groups having 35 patients each were formed. Group I: Received oral Ivabradine 5 mg, Group II: Received oral Clonidine 0.1 mg & Group III received placebo one hour before intubation. Intraocular Pressure (IOP) was measured with schiotz tonometer preoperatively & at various intervals to assess the effect of clonidine and Ivabradine on IOP. Results: A total of 105 pateints were enrolled. Three groups having 35 patients each were formed. The mean IOP of the patients from 3 groups were comparable initially (p - 0.082). At all later time points, the mean IOP of patients from 3 groups was statistically different (p < 0.001). The mean IOP in patients who received clonidine was significantly lesser as compared to control group at all time points except at the baseline (p < 0.001). However, among patients who received Ivabradine, the mean IOP was significantly less than the control group only at T1, and T7.Conclusions: Oral Clonidine can be recommended as premedicant for obtunding the rise in IOP following endotracheal intubation using succinylcholine. Oral Ivabradine showed no effect on IOP during endotracheal intubation using succinylcholine.

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