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Comparative Evaluation of Clonidine and Nalbuphine for Control of PostSpinal Anaesthesia Shivering
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Why is it important?
The aim of this study was to evaluate the efficacy, potency and side effects of clonidine and nalbuphinen in postspinal anesthesia shivering. In this prospective double-blind randomized controlled clinical trial, 60 American Society of ASA Grade I and II patients aged between 18 and 60 years scheduled for various surgical procedures under spinal anesthesia, who developed shivering were selected. The patients were divided into Two Groups: Group C (n = 30) comprised of patients who received clonidine 1 mcg/kg intravenously (IV) and Group N patients who received nalbuphine 0.05 mg/kg IV. Grade of shivering, disappearance of shivering, hemodynamic and side effects were observed at scheduled intervals. Disappearance of shivering was significantly earlier in Group C (2.75 ± 1.35) than in Group N (3.58 ± 1.19) (p = 0.01704). Bradycardia is seen more in Group C than Group N (p = < 0.001). Whereas, sedation is seen in Group N after drug administration but patient remain hemodynamically stable in Group N. We conclude that both the drugs are effective but nalbuphine controls shivering with more hemodynamic stability.
Perspectives
The aim of this study was to evaluate the efficacy, potency and side effects of clonidine and nalbuphinen in postspinal anesthesia shivering. In this prospective double-blind randomized controlled clinical trial, 60 American Society of ASA Grade I and II patients aged between 18 and 60 years scheduled for various surgical procedures under spinal anesthesia, who developed shivering were selected. The patients were divided into Two Groups: Group C (n = 30) comprised of patients who received clonidine 1 mcg/kg intravenously (IV) and Group N patients who received nalbuphine 0.05 mg/kg IV. Grade of shivering, disappearance of shivering, hemodynamic and side effects were observed at scheduled intervals. Disappearance of shivering was significantly earlier in Group C (2.75 ± 1.35) than in Group N (3.58 ± 1.19) (p = 0.01704). Bradycardia is seen more in Group C than Group N (p = < 0.001). Whereas, sedation is seen in Group N after drug administration but patient remain hemodynamically stable in Group N. We conclude that both the drugs are effective but nalbuphine controls shivering with more hemodynamic stability.
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This page is a summary of: Comparative Evaluation of Clonidine and Nalbuphine for Control of PostSpinal Anaesthesia Shivering, Indian Journal of Anaesthesia and Analgesia, January 2020, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.7120.32.
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