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Comparative Evaluation of Efficacy and Safety of Intravenous Propofol and Dexmedetomidine
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Aims: Comparing Propofol and Dexmedetomidine to assess the relative safety and efficacy in achieving adequate intraoperative sedation (Ramsay Sedation Score of 3–4) and cardiorespiratory safety in patients undergoing abdominal hysterectomy under subarachnoid block. Setting and Design: Department of Anesthesiology pain & Palliative Medicine, ESI PGISMR and Hospital, Manicktala (Tertiary Care Government Hospital located in Kolkata, WB, India) Operation theatres, Postanesthesia Care Unit, Gynecology & Maternity Ward. Study Design: Uni-centric prospective double blinded comparative Statistical analysis used: With ShapiroWilk test and Chi-square test Materials and Methods: Forty female participants between 18 and 65 years of age were divided into two groups via systematic random sampling. After administering subarachnoid block with 15 milligrams of 0.5% hyperbaric bupivacaine, bolus IV Dexmedetomidine (Group D, n = 20) or Propofol (Group P, n = 20) was started. All patients were monitored. Dexmedetomidine and Propofol infusions were discontinued at the end of surgery and the patients were transferred to the Postanesthasia Care Unit (PACU). The modified Aldrete scoring system was used to assess the readiness for shifting the patients to the postsurgical wards. Results: Both the groups had comparable demographics and basal values of heart rate, blood pressure, respiratory rate, ASA physical status, duration of infusion, depth of sedation, incidence of hypotension, bradycardia, over-sedation, but Group P had higher incidence of transient respiratory depression which were easily manageable.
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Aims: Comparing Propofol and Dexmedetomidine to assess the relative safety and efficacy in achieving adequate intraoperative sedation (Ramsay Sedation Score of 3–4) and cardiorespiratory safety in patients undergoing abdominal hysterectomy under subarachnoid block. Setting and Design: Department of Anesthesiology pain & Palliative Medicine, ESI PGISMR and Hospital, Manicktala (Tertiary Care Government Hospital located in Kolkata, WB, India) Operation theatres, Postanesthesia Care Unit, Gynecology & Maternity Ward. Study Design: Uni-centric prospective double blinded comparative Statistical analysis used: With ShapiroWilk test and Chi-square test Materials and Methods: Forty female participants between 18 and 65 years of age were divided into two groups via systematic random sampling. After administering subarachnoid block with 15 milligrams of 0.5% hyperbaric bupivacaine, bolus IV Dexmedetomidine (Group D, n = 20) or Propofol (Group P, n = 20) was started. All patients were monitored. Dexmedetomidine and Propofol infusions were discontinued at the end of surgery and the patients were transferred to the Postanesthasia Care Unit (PACU). The modified Aldrete scoring system was used to assess the readiness for shifting the patients to the postsurgical wards. Results: Both the groups had comparable demographics and basal values of heart rate, blood pressure, respiratory rate, ASA physical status, duration of infusion, depth of sedation, incidence of hypotension, bradycardia, over-sedation, but Group P had higher incidence of transient respiratory depression which were easily manageable.
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This page is a summary of: Comparative Evaluation of Efficacy and Safety of Intravenous Propofol and Dexmedetomidine for Intraoperative Sedation during Subarachnoid block: A Prospective Study, Indian Journal of Anaesthesia and Analgesia, January 2020, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.7120.28.
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