Comparison of Granisetron and Ondansetron on the Spinal Anesthesia Induced Hypotension, Bradycardia

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Comparison of Granisetron and Ondansetron on the Spinal Anesthesia Induced Hypotension, Bradycardia

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Background: Spinal anesthesia is easy to perform and provides a rapid-onset, dense surgical block. It is associated with hypotension and bradycardia, which may be deleterious to both mother and baby1. Various preventive methods are used to prevent or minimize hypotension including uterine displacement, fluid preloading, and compression stocking the lower extremities.2This study compares the effectiveness of Granisetron and Ondansetron on the spinal anesthesia induced hypotension, bradycardia after intrathecal hyperbaric Bupivacaine in patients undergoing cesarean sections. Materials and Methods: Sixty full-term patients posted for cesarean section belonging to ASA I or II were randomly assigned to Two Groups each containing 30 patients. Group G received 1 mg Granisetron and Group O received 4mg Ondansetron. Hemodynamic were noted at regularly along with APGAR score. Results: Trend observed in heart rate following the administration of the test drugs in both the groups and was not significant. The baseline hemodynamic of the patients were insignificant in both the Groups. This continued to be the case for up to 5 minutes after delivery of the drugs. At 10, 20, 30 and 45 minutes however, all three parameters were higher in Group O than Group G. At 60 mins however, no significant difference is seen between the groups. Similar trend was observed in APGAR score in neonates of both the Groups. Conclusion: Ondansetron was more effective in attenuation of spinal anesthesia induced hypotension than in Granisetron. Both the Groups had no significant difference in prevention of bradycardia oxygen saturation and foetal outcome.

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