Comparative Study of Magnesium Sulphate Nebulization and Lignocaine Nebulization in Prevention

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Comparative Study of Magnesium Sulphate Nebulization and Lignocaine Nebulization in Prevention

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Introduction: General anesthesia is an integral part of anesthesia and intubation is a necessary step to protect the airway from regurgitation and aspiration. Postoperative sore throat, hoarseness of voice, cough are common sequelae after endotracheal intubation. The present study was conducted to compare the efficiency of preoperative nebulization of lignocaine hydrochloride and magnesium sulphate for reducing the incidence of POST in patients undergoing surgeries in general anesthesia. Aims and Objective: The purpose and aim of the study was to compare the efficiency of preoperative nebulization of lignocaine hydrochloride and magnesium sulphate in reducing the incidence of POST following GA with regards to- Postoperative Sore Throat (POST), Cough hoarseness of voice, dysphagia and dysphonia and Complications from possible systemic effects, because of absorption from mucosal surfaces. Materials and Methods: 100 patients of Government Medical College, Kota, and attached group of hospitals, scheduled to undergo elective surgery lasting more than 1 hour but less than three hours under GA requiring tracheal intubation within the age group 40–70 years, of both sexes were randomly allocated in two groups by simple randomization using computer generated numbers. Group A: 50 patients received nebulized magnesium sulphate 4 ml. (6.25%). Group B: 50 patients received nebulized lignocaine 4 ml. (2%). Results: On Intergroup comparison incidence of sore throat was more common in Lignocaine Group as compared to Magnesium Group but there was no significant difference in both Groups with respect to sore throat at rest (p > 0.05). On Intragroup comparison incidence of hoarseness of voice decrease with time in both groups but more faster recovery in Magnesium Group. In Magnesium Group no incidence of hoarseness of voice found at 24 hr after extubation. In Lignocaine group no incidence of hoarseness of voice found at 48 hr after extubation.

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