What is it about?
Verapamil as an Adjunct to Local Anesthetic Solution for Supraclavicular Brachial Plexus Block
Featured Image
Photo by Annie Spratt on Unsplash
Why is it important?
Introduction: Calcium permeability is reduced by local anesthetics, and calcium ions play an important role in opioid-receptor mediated analgesia. The aim of this study is to evaluate whether addition of verapamil into local anesthetic for brachial plexus block provide additional anesthetic and analgesic effects. Methodology: Sixty patients undergoing upper extremity surgery were randomized to either Group A (20 ml of 1% lignocaine, 20 ml of 0.25% bupivacaine, 1 ml normal saline) or Group B (20 ml of 1% lignocaine, 20 ml of 0.25% bupivacaine, 1 ml 2.5 mg verapamil). Results: Baseline characteristics like age, gender distribution and body weight were similar in both the study groups. Mean duration of sensory block was found to be significantly higher in the group of patients receiving verapamil (191 ± 45.59 minutes vs 163 ± 45.72 minutes; p value < 0.01). Rest of the parameters like mean time of onset of sensory and motor block, duration of motor block and duration of analgesia were similar in both the study groups. There was no difference in the proportions of hemodynamic complications like heart rate, systolic blood pressure and oxygen saturation among the patients in the two groups as well. Conclusions: Our results show that adding verapamil to brachial plexus block can prolong sensory block. However, no change in analgesic properties or hemodynamic changes was observed.
Perspectives
Introduction: Calcium permeability is reduced by local anesthetics, and calcium ions play an important role in opioid-receptor mediated analgesia. The aim of this study is to evaluate whether addition of verapamil into local anesthetic for brachial plexus block provide additional anesthetic and analgesic effects. Methodology: Sixty patients undergoing upper extremity surgery were randomized to either Group A (20 ml of 1% lignocaine, 20 ml of 0.25% bupivacaine, 1 ml normal saline) or Group B (20 ml of 1% lignocaine, 20 ml of 0.25% bupivacaine, 1 ml 2.5 mg verapamil). Results: Baseline characteristics like age, gender distribution and body weight were similar in both the study groups. Mean duration of sensory block was found to be significantly higher in the group of patients receiving verapamil (191 ± 45.59 minutes vs 163 ± 45.72 minutes; p value < 0.01). Rest of the parameters like mean time of onset of sensory and motor block, duration of motor block and duration of analgesia were similar in both the study groups. There was no difference in the proportions of hemodynamic complications like heart rate, systolic blood pressure and oxygen saturation among the patients in the two groups as well. Conclusions: Our results show that adding verapamil to brachial plexus block can prolong sensory block. However, no change in analgesic properties or hemodynamic changes was observed.
Red Flower Publication Publications
Red Flower Publication Pvt Ltd
Read the Original
This page is a summary of: Verapamil as an Adjunct to Local Anesthetic Solution for Supraclavicular Brachial Plexus Block, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6619.7.
You can read the full text:
Contributors
The following have contributed to this page
