What is it about?
A Comparative Study on Pre-emptive Analgesic Effect of IV Paracetamol on Reducing the Use of Opioid
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Why is it important?
Background: Present study was undertaken to see the pre-emptive efficacy of IV paracetamol and reduction in the use of opioid for post-operative pain management. Aim and Objective: To study pre-emptive analgesic effects of 1 gm paracetamol infusion on the total requirement of tramadol in the post-operative period including rescue analgesia. Methods: After ethical approval present study was carried out NSCB Medical College, Jabalpur from October 2009 to September 2010, 90 patients of ASA class I and II between the age group of 20–60 years undergoing elective abdominal surgery were included in the study. Patients were divided into 3 Groups of 30 patients each. Group I was given IV paracetamol infusion 1gm for 15–20 minutes, 30 minutes prior to induction. Group II was IV paracetamol infusion 1 gm for 15–20 minutes prior to skin closure, and Group III received normal saline as placebo. Post-operatively pain (VAS) scores, sedation scores, postoperative tramadol doses, side effects were recorded. Results: Group III, VAS score was significantly higher (p < 0.01) as compare to Group I. Consumption of tramadol in Group III was significantly higher (p < 0.01) compared to Groups I and II. Conclusion: IV paracetamol infusion pre-emptive ensure effective analgesia and decreases tramadol consumption and side effects.
Perspectives
Background: Present study was undertaken to see the pre-emptive efficacy of IV paracetamol and reduction in the use of opioid for post-operative pain management. Aim and Objective: To study pre-emptive analgesic effects of 1 gm paracetamol infusion on the total requirement of tramadol in the post-operative period including rescue analgesia. Methods: After ethical approval present study was carried out NSCB Medical College, Jabalpur from October 2009 to September 2010, 90 patients of ASA class I and II between the age group of 20–60 years undergoing elective abdominal surgery were included in the study. Patients were divided into 3 Groups of 30 patients each. Group I was given IV paracetamol infusion 1gm for 15–20 minutes, 30 minutes prior to induction. Group II was IV paracetamol infusion 1 gm for 15–20 minutes prior to skin closure, and Group III received normal saline as placebo. Post-operatively pain (VAS) scores, sedation scores, postoperative tramadol doses, side effects were recorded. Results: Group III, VAS score was significantly higher (p < 0.01) as compare to Group I. Consumption of tramadol in Group III was significantly higher (p < 0.01) compared to Groups I and II. Conclusion: IV paracetamol infusion pre-emptive ensure effective analgesia and decreases tramadol consumption and side effects.
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This page is a summary of: A Comparative Study on Pre-emptive Analgesic Effect of IV Paracetamol on Reducing the Use of Opioid in Post-operative Pain Management, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6619.41.
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