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An Observational Study of Small Dose Propofol and Midazolam as Co-induction Agents to Propofol
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Why is it important?
Introduction: Propofol has become the most widely used I.V. hypnotic agent. It provides rapid induction but the major disadvantages are cardiovascular and respiratory dysfunction hence, the concept of “Auto-coinduction” and “Co-induction” has come forward. The current study, has been designed to evaluate reduction in induction doses of propofol and alteration in peri-intubation hemodynamic in propofol auto-co-induction and midazolam propofol co-induction groups along with propofol group. Materials and Methods: The present study, is a prospective, observational and non-interventional study, which includes 75 patients of age between 20 and 50 years with ASA grade I. All the patients were divided into three groups and each group have 25 patients Group I (PP), Group II (MP), Group III (P). Two minutes prior to induction agent Group I received 0.5 mg/kg propofol, Group II received 0.05 mg/kg midazolam. Induction dose of propofol and hemodynamic parameters during various interval were measured. Results: Propofol induction dose in Group I,II,III, was 74.4 mg, 66.36 mg and 136.4 mg respectively which was statically significant (p < 0.05) when group Iand II compare with group III. Hemodynamic stability in peri-intubation period was better in group I that mean auto-co-induction. Conclusion: We conclude that midazolam co-induction and propofol auto-co-induction significantly reduce the induction dose of propofol, propofol auto-co-induction provides better hemodynamic stability in peri-intubation period. The priming appears to be cost effective by significantly reducing the total dose of propofol required and no significant adverse intra-operative or post-operative effects were observed in all groups.
Perspectives
Introduction: Propofol has become the most widely used I.V. hypnotic agent. It provides rapid induction but the major disadvantages are cardiovascular and respiratory dysfunction hence, the concept of “Auto-coinduction” and “Co-induction” has come forward. The current study, has been designed to evaluate reduction in induction doses of propofol and alteration in peri-intubation hemodynamic in propofol auto-co-induction and midazolam propofol co-induction groups along with propofol group. Materials and Methods: The present study, is a prospective, observational and non-interventional study, which includes 75 patients of age between 20 and 50 years with ASA grade I. All the patients were divided into three groups and each group have 25 patients Group I (PP), Group II (MP), Group III (P). Two minutes prior to induction agent Group I received 0.5 mg/kg propofol, Group II received 0.05 mg/kg midazolam. Induction dose of propofol and hemodynamic parameters during various interval were measured. Results: Propofol induction dose in Group I,II,III, was 74.4 mg, 66.36 mg and 136.4 mg respectively which was statically significant (p < 0.05) when group Iand II compare with group III. Hemodynamic stability in peri-intubation period was better in group I that mean auto-co-induction. Conclusion: We conclude that midazolam co-induction and propofol auto-co-induction significantly reduce the induction dose of propofol, propofol auto-co-induction provides better hemodynamic stability in peri-intubation period. The priming appears to be cost effective by significantly reducing the total dose of propofol required and no significant adverse intra-operative or post-operative effects were observed in all groups.
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This page is a summary of: An Observational Study of Small Dose Propofol and Midazolam as Co-induction Agents to Propofol, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6519.10.
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