Comparison of Levobupivacaine with or without Epinephrine for Lumbar Spine Surgery

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Comparison of Levobupivacaine with or without Epinephrine for Lumbar Spine Surgery

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Introduction: The aim was to establish if a decrease in the amount of epinephrine from 1:200,000 to 1:400,000 added to epidural levobupivacaine produces a comparable decrease in local anaesthetic assimilation from the epidural space while holding the similar clinical effectiveness and acceptability in patients undergoing elective lumbar spine surgery. Materials and Methods: A total of 120 patients with ASA physical status 1 to 3 and aged 18 – 85 years, who were schedule to undergo elective lumbar spine surgery, were enrolled for the study. Total dose of 75 mg was administered. The end of injection of study drug was termed “Time 0” for the purposes of subsequent patient assessment. Intraoperative sedation was offered with added IV midazolam and propofol as essential at the judgment of the anaesthesiologist. Results: Levobupivacaine 0.5% produces comparatively small motor blockade. In fact, in 53% of all patients studied, no motor block of the lower extremities could be demonstrated. even though the addition of either 1:200,000 or 1:400,00 epinephrine tended to increase the degree of motor blockade, it was not statistical significance. in addition, in those patients who did build up some degree of motor blockade, its period was not diverse among both the groups. Conclusion: Present Study reveals that 0.5% levobupivacaine, with or without epinephrine, is a appropriate anaesthetic for utilize in lumbar spine surgery. The addition of epinephrine be likely to increase the duration of blockade, diminish the ensuing local anaesthetic concentration, and advance intraoperative anaesthetic quality, even though statistical significance was not there for any T10 was achieved within 15 minutes of administering the epidural injection in all patient groups.

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