What is it about?
Study to Evaluate the Role of Vasopressin in Hypernatremia Treatment in Brain-Dead Patients
Featured Image
Photo by David Matos on Unsplash
Why is it important?
Brain dead patients are potential organ donors but the pathological changes associated with braindeath can affect graft survival. Among various effects of braindeath endocrine and autonomic changes are noteworthy. Central diabetes insipidus characterized by reduced level of anti-diuretic hormone in brain dead patients can result in hypernatremia which inturn may affect the survival of the transplanted liver graft. Managing hypernatremia with exogenous vasopressin replacement improves the liver graft function.Vasopressin also maintains haemodynamic stability and reduce excessive free water loss as urine. It is given as intravenous infusion at 0.01-0.04 U/min or maximum 2.4U/hour.
Perspectives
Brain dead patients are potential organ donors but the pathological changes associated with braindeath can affect graft survival. Among various effects of braindeath endocrine and autonomic changes are noteworthy. Central diabetes insipidus characterized by reduced level of anti-diuretic hormone in brain dead patients can result in hypernatremia which inturn may affect the survival of the transplanted liver graft. Managing hypernatremia with exogenous vasopressin replacement improves the liver graft function.Vasopressin also maintains haemodynamic stability and reduce excessive free water loss as urine. It is given as intravenous infusion at 0.01-0.04 U/min or maximum 2.4U/hour.
Red Flower Publication Publications
Red Flower Publication Pvt Ltd
Read the Original
This page is a summary of: Prospective Study to Evaluate the Role of Vasopressin in Hypernatremia Treatment in Brain Dead Patients, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6419.35.
You can read the full text:
Contributors
The following have contributed to this page
