What is it about?
Effects of Clonidine on Spinal Anesthesia with Hyperbaric Bupivacaine
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Why is it important?
Background: Clonidine is one of the drugs that have been extensively studied by administering through oral, intravenous and intrathecal routes to prolong the spinal anesthesia. A lot of studies have shown oral clonidine premedication to prolong duration of sensory block and motor block. This study is undertaken to evaluate the effect of oral clonidine as premedicant on spinal anesthesia with 0.5% hyperbaric bupivacaine. Methods: A double blind randomized controlled study was carried out on 100 participants who underwent elective surgeries under spinal anesthesia. The participants were allocated into experimental (oral Clonidine) and control group (50 each) equally. Heart rate, level and duration of sensory and motor blockades were observed. Results: The mean time to highest sensory blockade was lower in experimental group (5.28 min) when compared to control group (7.76 min). The observed difference was statistically significant (p<0.001). Similarly, there was a statistically significant difference in the mean duration of motor blockade between the groups, wherein the experimental group had a longer duration (264 min) compared to the control group (208.50 min) (Table 4). Conclusion: Premedication with oral clonidine 150μg, 1 hour prior to spinal anesthesia is adequate to provide clinically useful prolongation of sensory blockade without significant adverse effects.
Perspectives
Background: Clonidine is one of the drugs that have been extensively studied by administering through oral, intravenous and intrathecal routes to prolong the spinal anesthesia. A lot of studies have shown oral clonidine premedication to prolong duration of sensory block and motor block. This study is undertaken to evaluate the effect of oral clonidine as premedicant on spinal anesthesia with 0.5% hyperbaric bupivacaine. Methods: A double blind randomized controlled study was carried out on 100 participants who underwent elective surgeries under spinal anesthesia. The participants were allocated into experimental (oral Clonidine) and control group (50 each) equally. Heart rate, level and duration of sensory and motor blockades were observed. Results: The mean time to highest sensory blockade was lower in experimental group (5.28 min) when compared to control group (7.76 min). The observed difference was statistically significant (p<0.001). Similarly, there was a statistically significant difference in the mean duration of motor blockade between the groups, wherein the experimental group had a longer duration (264 min) compared to the control group (208.50 min) (Table 4). Conclusion: Premedication with oral clonidine 150μg, 1 hour prior to spinal anesthesia is adequate to provide clinically useful prolongation of sensory blockade without significant adverse effects.
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This page is a summary of: Effects of Clonidine on Spinal Anesthesia with Hyperbaric Bupivacaine, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6419.32.
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