What is it about?

Efficacy of Intraoperative Dexmedetomidine on Emergence from Anesthesia and on Recovery

Featured Image

Why is it important?

Context: Emergence agitation is a post anesthetic phenomenon commonly associated with ENT surgeries. We studied the effects of maintenance infusion of Dexmedetomidine on prevention of Emergence agitation in adult patients undergoing FESS. Aims: To see the effects of intraoperative dexmedetomidine infusion on incidence of emergence agitation and recovery characteristics in terms of cough, pain and nausea vomiting scores. Settings and Design: A prospective, randomized, controlled, double blinded comparative study done at our institute. Methods and Material: One hundred patients undergoing FESS surgery were randomized into two groups. Group D (n=50) received dexmedetomidine infusion at a rate of 0.5 μg kg−1 hr−1 from induction of anesthesia until extubation, while group C (n=50) received volume-matched normal saline infusion. The incidence of agitation and recovery characteristics in terms of Cough score, Nausea vomiting score and Pain scores were evaluated in both groups. Statistical analysis used: Parametric data were analyzed using oneway ANOVA and the Student’s paired t-test where appropriate. Non parametric data were analyzed using Chi-square test. A value of p < 0.05 was considered statistically signicant. Results: The incidence of Emergence Agitation (Ricker sedation agitation score ≥ 5) was higher in group C compared to group D (p <0.001). Recovery characteristics in terms of Cough score (p=0.118) and Nausea vomiting score (p=0.589) were similar in both groups, while Pain score was higher in Group C compared to Group D (p<0.001). Increase in Heart rate and MAP at emergence was more in Group C compared to Group D. Conclusions: Dexmedetomidine as an adjuvant to general anesthesia for FESS is an excellent drug to reduce Emergence agitation, provide better postoperative pain relief and also maintains stable hemodynamics at emergence.

Perspectives

Context: Emergence agitation is a post anesthetic phenomenon commonly associated with ENT surgeries. We studied the effects of maintenance infusion of Dexmedetomidine on prevention of Emergence agitation in adult patients undergoing FESS. Aims: To see the effects of intraoperative dexmedetomidine infusion on incidence of emergence agitation and recovery characteristics in terms of cough, pain and nausea vomiting scores. Settings and Design: A prospective, randomized, controlled, double blinded comparative study done at our institute. Methods and Material: One hundred patients undergoing FESS surgery were randomized into two groups. Group D (n=50) received dexmedetomidine infusion at a rate of 0.5 μg kg−1 hr−1 from induction of anesthesia until extubation, while group C (n=50) received volume-matched normal saline infusion. The incidence of agitation and recovery characteristics in terms of Cough score, Nausea vomiting score and Pain scores were evaluated in both groups. Statistical analysis used: Parametric data were analyzed using oneway ANOVA and the Student’s paired t-test where appropriate. Non parametric data were analyzed using Chi-square test. A value of p < 0.05 was considered statistically signicant. Results: The incidence of Emergence Agitation (Ricker sedation agitation score ≥ 5) was higher in group C compared to group D (p <0.001). Recovery characteristics in terms of Cough score (p=0.118) and Nausea vomiting score (p=0.589) were similar in both groups, while Pain score was higher in Group C compared to Group D (p<0.001). Increase in Heart rate and MAP at emergence was more in Group C compared to Group D. Conclusions: Dexmedetomidine as an adjuvant to general anesthesia for FESS is an excellent drug to reduce Emergence agitation, provide better postoperative pain relief and also maintains stable hemodynamics at emergence.

Red Flower Publication Publications
Red Flower Publication Pvt Ltd

Read the Original

This page is a summary of: Efficacy of Intraoperative Dexmedetomidine on Emergence from Anesthesia and on Recovery Characteristics after FESS (Functional Endoscopic Sinus Surgery), Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6319.40.
You can read the full text:

Read

Contributors

The following have contributed to this page