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Comparative Evaluation of two Different Intravenous Doses of Midazolam to Aid the Insertion of LMA

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Background: Propofol is a widely accepted medication for the uccessful insertion of laryngeal mask airway, but as a sole induction agent, it has a very low success rate. A number of co-induction agents have been used with propofol to increase the success rate of LMA insertion. Aim and Objectives: To evaluate the efficacy of two different doses of midazolam i.e. 0.05 mg/kg and 0.08 mg/kg intravenously when used with propofol versus propofol alone for LMA insertion. To find the appropriate dose of midazolam that provides ideal condition and maximum haemodynamic stability. Material & Methods: 75 adult patients of ASA I & II grade randomly divided into 3 groups. Group P: Propofol + Saline Group PM1: Midazolam 0.05 mg/kg 3 minutes before propofol + Propofol Group PM2: Midazolam 0.08 mg/kg 3 minutes before propofol + Propofol. LMA insertion attempted 1 minute after the administration of Propofol. Total dose of propofol used, the insertion conditions and haemodynamic changes were noted. Results: There was no statistical difference in demographic profile. Haemodynamically patients were more stable in group PM1 & PM2 than in group P. Dose of propofol used in PM2 (2.05+0.21 in mg/kg) & PM1 (2.38+0.21) was less than in Group P (2.84 mg/kg). 100% success rate in LMA insertion was observed in group PM1 & PM2 in first attempt whereas it was 80% in group P. 88% in group PM2, 60% in group PM1 & only 32% patients in group P had excellent insertion conditions. Conclusion: Propofol as a sole agent does not provide LMA insertion conditions. Midazolam when used with propofol provides adequate conditions for LMA insertion in a dose dependent manner.

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Background: Propofol is a widely accepted medication for the uccessful insertion of laryngeal mask airway, but as a sole induction agent, it has a very low success rate. A number of co-induction agents have been used with propofol to increase the success rate of LMA insertion. Aim and Objectives: To evaluate the efficacy of two different doses of midazolam i.e. 0.05 mg/kg and 0.08 mg/kg intravenously when used with propofol versus propofol alone for LMA insertion. To find the appropriate dose of midazolam that provides ideal condition and maximum haemodynamic stability. Material & Methods: 75 adult patients of ASA I & II grade randomly divided into 3 groups. Group P: Propofol + Saline Group PM1: Midazolam 0.05 mg/kg 3 minutes before propofol + Propofol Group PM2: Midazolam 0.08 mg/kg 3 minutes before propofol + Propofol. LMA insertion attempted 1 minute after the administration of Propofol. Total dose of propofol used, the insertion conditions and haemodynamic changes were noted. Results: There was no statistical difference in demographic profile. Haemodynamically patients were more stable in group PM1 & PM2 than in group P. Dose of propofol used in PM2 (2.05+0.21 in mg/kg) & PM1 (2.38+0.21) was less than in Group P (2.84 mg/kg). 100% success rate in LMA insertion was observed in group PM1 & PM2 in first attempt whereas it was 80% in group P. 88% in group PM2, 60% in group PM1 & only 32% patients in group P had excellent insertion conditions. Conclusion: Propofol as a sole agent does not provide LMA insertion conditions. Midazolam when used with propofol provides adequate conditions for LMA insertion in a dose dependent manner.

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This page is a summary of: Comparative Evaluation of two Different Intravenous Doses of Midazolam to Aid the Insertion of LMA Classic as Adjuvants to Propofol Anaesthesia, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6319.1.
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