What is it about?
To Compare the Efficacy of Midazolam and Triclofos as Oral Premedicant in Paediatric Patients
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Why is it important?
Context: The primary goals of premedication in children are to facilitate a smooth separation from the parents and to ease the induction of anesthesia. Aims: To compare the efficacy of midazolam and triclofos when given orally as premedicants in children. Material and methods: 50 patients aged 2-6 years of ASA I & II were divided randomly into two groups equally. Group M received syrup midazolam, 0.5 mg kg-1 and group T received syrup triclofos 75 mg kg-1, orally as premedication. Level of sedation and behavior [1,3] at the time of separation from parents and during mask acceptance [1,3]. Statistical analysis: Unpaired t-test was used for statistical analysis. p-value <0.05 is significant. Results: In group-M 56% and 40% patients while in group-T 24% and 8% patients achieved a sedation score of 4 and 5 respectively (p<0.05). In group-T 64% and 24% while in group-M 8% and 12% patients achieved a behavior score of 1 and 2 respectively at the time of separation from parents (p<0.05). In group-M 68% and in group-T 24% patients achieved a mask acceptance score of 4 (p<0.05). Conclusion: Oral midazolam 0.5 mg kg-1 was better in terms of level of sedation and behavior at the time of mask acceptance whereas, triclofos 75 mg kg-1 was better in terms of behavior at the time of separation from parents in paediatric age group 2 to 6 years. Hence, midazolam was found to be superior to triclofos.
Perspectives
Context: The primary goals of premedication in children are to facilitate a smooth separation from the parents and to ease the induction of anesthesia. Aims: To compare the efficacy of midazolam and triclofos when given orally as premedicants in children. Material and methods: 50 patients aged 2-6 years of ASA I & II were divided randomly into two groups equally. Group M received syrup midazolam, 0.5 mg kg-1 and group T received syrup triclofos 75 mg kg-1, orally as premedication. Level of sedation and behavior [1,3] at the time of separation from parents and during mask acceptance [1,3]. Statistical analysis: Unpaired t-test was used for statistical analysis. p-value <0.05 is significant. Results: In group-M 56% and 40% patients while in group-T 24% and 8% patients achieved a sedation score of 4 and 5 respectively (p<0.05). In group-T 64% and 24% while in group-M 8% and 12% patients achieved a behavior score of 1 and 2 respectively at the time of separation from parents (p<0.05). In group-M 68% and in group-T 24% patients achieved a mask acceptance score of 4 (p<0.05). Conclusion: Oral midazolam 0.5 mg kg-1 was better in terms of level of sedation and behavior at the time of mask acceptance whereas, triclofos 75 mg kg-1 was better in terms of behavior at the time of separation from parents in paediatric age group 2 to 6 years. Hence, midazolam was found to be superior to triclofos.
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This page is a summary of: To Compare the Efficacy of Midazolam and Triclofos as Oral Premedicant in Paediatric Patients, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6219.27.
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