What is it about?
Study of Intrathecal Levobupivacaine with Fentanyl Verses Clonidine for Infraumblical Surgeries
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Why is it important?
Background and aims: Subarachnoid block can be performed with many local anaesthetic agents. Besides hyperbaric bupivacaine even isobaric levobupivacaine and ropivacaine can also be used with minimal cardiotoxicity. Adjuvants like opiods and alpha-2 agonist prolongs the duration of levobupivacaine action. The aim of the present study is to compare fentanyl and clonidine effect used as adjuvants to levobupivacaine with respect to onset of sensory and motor blockade; maximum level attained and the required for the same; duration of blockade and post operative analgesia. Materials and Methods: After ethical committee approval, 80 patients posted for infraumblical surgeries divided into two groups. Group LF received 15 mg of levobpivacaine with 25µg fentanyl whereas group LC received 15 mg of levobupivacaine with 30µg clonidine. The volume of solution was 3.5 ml in both groups. Hemodynamic, sensory and motor characteristics were monitored. Results: Onset of sensory and motor blockade as well as regression of both was faster with fentanyl than clonidine. There was slight fall in heart rate and mean arterial pressure in both the groups after intrathecal drugs but it was more with clonidine. Bradycardia and hypotension was noted more with clonidine than fentanyl which was easily manageable. Though the onset was delayed, sensory, motor and analgesic effect was prolonged with clonidine. Conclusion: Levobpiacaine can be safely used for spinal anaesthesia in infraumblical surgeries. Adding fentanyl causes early onset of action whereas clonidine has more prolonged action.
Perspectives
Background and aims: Subarachnoid block can be performed with many local anaesthetic agents. Besides hyperbaric bupivacaine even isobaric levobupivacaine and ropivacaine can also be used with minimal cardiotoxicity. Adjuvants like opiods and alpha-2 agonist prolongs the duration of levobupivacaine action. The aim of the present study is to compare fentanyl and clonidine effect used as adjuvants to levobupivacaine with respect to onset of sensory and motor blockade; maximum level attained and the required for the same; duration of blockade and post operative analgesia. Materials and Methods: After ethical committee approval, 80 patients posted for infraumblical surgeries divided into two groups. Group LF received 15 mg of levobpivacaine with 25µg fentanyl whereas group LC received 15 mg of levobupivacaine with 30µg clonidine. The volume of solution was 3.5 ml in both groups. Hemodynamic, sensory and motor characteristics were monitored. Results: Onset of sensory and motor blockade as well as regression of both was faster with fentanyl than clonidine. There was slight fall in heart rate and mean arterial pressure in both the groups after intrathecal drugs but it was more with clonidine. Bradycardia and hypotension was noted more with clonidine than fentanyl which was easily manageable. Though the onset was delayed, sensory, motor and analgesic effect was prolonged with clonidine. Conclusion: Levobpiacaine can be safely used for spinal anaesthesia in infraumblical surgeries. Adding fentanyl causes early onset of action whereas clonidine has more prolonged action.
Red Flower Publication Publications
Red Flower Publication Pvt Ltd
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This page is a summary of: A Randomised Prospective Double Blinded Study of Intrathecal Levobupivacaine with Fentanyl Verses Clonidine for Infraumblical Surgeries, Indian Journal of Anaesthesia and Analgesia, January 2019, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.6119.34.
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