What is it about?
Observational Study to Compare Etomidate and Thiopentone as Inducing Agents in General Anaesthesia
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Why is it important?
Background and Objective: The clinical study was undertaken to evaluate the efficacy of Thiopentone & Etomidate with reference to time to loss of eyelash reflex, hemodynamic parameters, pain on injection, myoclonus & other side effects if any. Material and Method: Study was conducted on 60 patients (according to Solvin’s formula) of either gender, ASA I & II, 20- 60 years old, posted for elective surgeries for general surgery and Ear Nose and Throat surgery. All the patients were premedicated with inj. Fentanyl 2 mcg/kg iv slowly along with other pre medicating drugs and divided into 2 groups. Group E induced with inj. Etomidate 0.3 mg/kg iv and the group T induced with inj. Thiopentone 5 mg/kg iv. The induction time was calculated from the start of injection to the loss of eyelash reflex. The patient’s hemodynamic changes during baseline, at the time of induction and 1 min, 2 mins, 5 mins & 10 mins after the induction were recorded. Pain on injectionand myoclonus were recorded during induction and other side effects were noted. Results: Induction time was faster in Group E (23.23±5.2 seconds) when compared with group T (32.60±4.5 seconds) (p value<0.05). Hemodynamic changes were more stable in group E and Pain on injection and Myoclonus were observed only in group E (8 & 10 patients respectively). Conclusion: Etomidate causes good hemodynamic stability with rapid induction than Thiopentone.
Perspectives
Background and Objective: The clinical study was undertaken to evaluate the efficacy of Thiopentone & Etomidate with reference to time to loss of eyelash reflex, hemodynamic parameters, pain on injection, myoclonus & other side effects if any. Material and Method: Study was conducted on 60 patients (according to Solvin’s formula) of either gender, ASA I & II, 20- 60 years old, posted for elective surgeries for general surgery and Ear Nose and Throat surgery. All the patients were premedicated with inj. Fentanyl 2 mcg/kg iv slowly along with other pre medicating drugs and divided into 2 groups. Group E induced with inj. Etomidate 0.3 mg/kg iv and the group T induced with inj. Thiopentone 5 mg/kg iv. The induction time was calculated from the start of injection to the loss of eyelash reflex. The patient’s hemodynamic changes during baseline, at the time of induction and 1 min, 2 mins, 5 mins & 10 mins after the induction were recorded. Pain on injectionand myoclonus were recorded during induction and other side effects were noted. Results: Induction time was faster in Group E (23.23±5.2 seconds) when compared with group T (32.60±4.5 seconds) (p value<0.05). Hemodynamic changes were more stable in group E and Pain on injection and Myoclonus were observed only in group E (8 & 10 patients respectively). Conclusion: Etomidate causes good hemodynamic stability with rapid induction than Thiopentone.
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This page is a summary of: An Observational Study to Compare Etomidate and Thiopentone as Inducing Agents in General Anaesthesia for Patients Posted under General and ENT Surgeries, Indian Journal of Anaesthesia and Analgesia, January 2018, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.5318.7.
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