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Ropivacaine versus Dexmedetomidine and Ropivacaine by Epidural Anaesthesia in Lower Limb Surgeries

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Aim: To evaluate the effect of ropivacaine versus Dexmedetomidine and ropivacaine in epidural anaesthesia in lower abdominal surgeries. Materials and Methods: This study is a prospective double blinded randomized study which was carried out on 100 patients who were admitted in Department of Anaesthesia in Government Medical College Gulbarga & ESIC Medical College, Gulbarga, Karnataka. This study was conducted in the period of 2014 to 2017. Patients were randomly divided in to two groups each of 50 each, which were Group A in which ropivacaine and normal saline were administered, Group B in which ropivacaine and dexmedetomidine were administered. Results: There was no statistical significant variation between the two groups with respect to age, height, weight and ASA I/II grading (p>0.05). The mean onset of analgesia in group A was 11.33±1.89, in group B was 8.99±0.97, the mean time to attain maximum sensory level was 15.00±1.45 in group A and in group B, it was 12.58±2.58, the mean time for complete motor block was 20.41±1.47 in group A and in group B it was 15.22±2.89. Mean time to two segment regression was 95.85±5.48 in group A and in group B it was 161.59±9.87, mean duration of analgesia was 201.25±4.26 in group A and in group B it was 290.87±8.99 and mean time to complete recovery of motor block was 133.49±5.87 in group A and in group B it was 214.21±4.25. Sedation score of 1 was observed in 12% patients in Group A, whereas in group B, 50% patients showed a score of 1 and 50% patients showed a score of 2. The sedation was more in group B compared to group A. Side effects are significantly more in group B compared to group A. (p=0.001). Conclusion: The onset of action, better analgesic effect with dexmedetomidine is fastened with the addition of alpha 2 agonists and incidence of side effects insignificantly.

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Aim: To evaluate the effect of ropivacaine versus Dexmedetomidine and ropivacaine in epidural anaesthesia in lower abdominal surgeries. Materials and Methods: This study is a prospective double blinded randomized study which was carried out on 100 patients who were admitted in Department of Anaesthesia in Government Medical College Gulbarga & ESIC Medical College, Gulbarga, Karnataka. This study was conducted in the period of 2014 to 2017. Patients were randomly divided in to two groups each of 50 each, which were Group A in which ropivacaine and normal saline were administered, Group B in which ropivacaine and dexmedetomidine were administered. Results: There was no statistical significant variation between the two groups with respect to age, height, weight and ASA I/II grading (p>0.05). The mean onset of analgesia in group A was 11.33±1.89, in group B was 8.99±0.97, the mean time to attain maximum sensory level was 15.00±1.45 in group A and in group B, it was 12.58±2.58, the mean time for complete motor block was 20.41±1.47 in group A and in group B it was 15.22±2.89. Mean time to two segment regression was 95.85±5.48 in group A and in group B it was 161.59±9.87, mean duration of analgesia was 201.25±4.26 in group A and in group B it was 290.87±8.99 and mean time to complete recovery of motor block was 133.49±5.87 in group A and in group B it was 214.21±4.25. Sedation score of 1 was observed in 12% patients in Group A, whereas in group B, 50% patients showed a score of 1 and 50% patients showed a score of 2. The sedation was more in group B compared to group A. Side effects are significantly more in group B compared to group A. (p=0.001). Conclusion: The onset of action, better analgesic effect with dexmedetomidine is fastened with the addition of alpha 2 agonists and incidence of side effects insignificantly.

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This page is a summary of: Ropivacaine versus Dexmedetomidine and Ropivacaine by Epidural Anaesthesia in Lower Limb Surgeries, Indian Journal of Anaesthesia and Analgesia, January 2018, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.5118.11.
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