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Comparative Study Intrathecal Bupivacaine with 50 and 75 µg Clonidine in Lower Abdominal Surgeries
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Why is it important?
Background: Spinal anaesthesia is a safe, reliable, inexpensive technique of providing anaesthesia and blunts autonomic, somatic and endocrine responses. It has many advantages; the limited duration of action appears to be one of its downsides. Clonidine, a partial 2 adrenoceptor agonist, has been shown as an effective and safe drug. It prolongs the action of local anaesthetics and reduces the dosage requirement. Aims: To compare the efficacy of intrathecal bupivacaine in combination with 50 µg and 75 µg of clonidine in lower abdominal surgeries. Materials and Methods: 60 patients scheduled for lower abdominal surgeries, aged 1865 years with ASA grade III satisfying inclusion criteria were recruited for the study and were randomly divided into two groups of 30 each. Group C50 received Inj. clonidine 50 µg added to 15mg hyperbaric bupivacaine and Group C75 received Inj. clonidine 75 µg added to 15mg hyperbaric bupivacaine. Spinal block characteristics, haemodynamic changes and side effects were recorded. Results: Onset of sensory and motor blockade was earlier in group C75 as compared to group C50 but statistically insignificant. Maximum sensory block achieved was T4 in group C75 and T5 in group C50. Two segment regression duration, duration of analgesia, duration of sensory blockade and motor blockade were statistically significantly prolonged in group C75 as compared to group C50. Patients maintained haemodynamic stability. Sedation scoring and side effects were comparable in both the groups. Data was analysed using Chisquare test and Independent t test. Conclusions: 75µg Clonidine when added to intrathecal bupivacaine prolongs anaesthesia and postoperative analgesia compared to clonidine 50µg.
Perspectives
Background: Spinal anaesthesia is a safe, reliable, inexpensive technique of providing anaesthesia and blunts autonomic, somatic and endocrine responses. It has many advantages; the limited duration of action appears to be one of its downsides. Clonidine, a partial 2 adrenoceptor agonist, has been shown as an effective and safe drug. It prolongs the action of local anaesthetics and reduces the dosage requirement. Aims: To compare the efficacy of intrathecal bupivacaine in combination with 50 µg and 75 µg of clonidine in lower abdominal surgeries. Materials and Methods: 60 patients scheduled for lower abdominal surgeries, aged 1865 years with ASA grade III satisfying inclusion criteria were recruited for the study and were randomly divided into two groups of 30 each. Group C50 received Inj. clonidine 50 µg added to 15mg hyperbaric bupivacaine and Group C75 received Inj. clonidine 75 µg added to 15mg hyperbaric bupivacaine. Spinal block characteristics, haemodynamic changes and side effects were recorded. Results: Onset of sensory and motor blockade was earlier in group C75 as compared to group C50 but statistically insignificant. Maximum sensory block achieved was T4 in group C75 and T5 in group C50. Two segment regression duration, duration of analgesia, duration of sensory blockade and motor blockade were statistically significantly prolonged in group C75 as compared to group C50. Patients maintained haemodynamic stability. Sedation scoring and side effects were comparable in both the groups. Data was analysed using Chisquare test and Independent t test. Conclusions: 75µg Clonidine when added to intrathecal bupivacaine prolongs anaesthesia and postoperative analgesia compared to clonidine 50µg.
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This page is a summary of: Comparative Study of Intrathecal Bupivacaine with 50 and 75 µg Clonidine in Lower Abdominal Surgeries, Indian Journal of Anaesthesia and Analgesia, January 2018, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.51118.13.
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