What is it about?
A Comparative Evaluation of Thiopentone Sodium and Propofol as Inducing Agent for Caesarean Section
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Why is it important?
The success of anaesthesia in obstetrics depends largely upon surgical demand and maternofoetal well being. Hence the aim of anaesthesia is to provide safety and comfort to the mother, minimal neonatal depression and optimal working condition for the obstetrician. Propofol 2.5 mg/kg was compared with thiopentone sodium 5mg/kg as induction agent for elective caesarean section. A total of 90 healthy pregnant patients of ASA I and II, who were scheduled for elective caesarean section were included in this study and were randomly allocated into 3 groups. Group I Thiopentone sodium 2.5% (5mg/kg), group II Propofol 0.5% (2 mg/kg) and group III Propofol 1% (2mg/kg). Induction was smooth and rapid with both Propofol and Thiopentone with minimal incidence of side effects. Induction time was found to be shortest with Propofol 1% (40.1±6.11 seconds) as compared to Thiopentone sodium 2.5% (47.2±7.26 seconds) and Propofol 0.5% (70.5±19.58 seconds). Mean arterial pressure was lower in Propofol 1% group during the induction and intraoperatively. Other hemodynamic changes were similar in all three groups. Apnoea occurred less frequently with Propofol 1% (10%) than with Thiopentone sodium (43.33%). Pain on injection (6.66%) and awareness (10%) was found with Propofol whereas cough (3.33%), hiccup (6.66%) and nausea & vomiting (33.33%) were observed with Thiopentone sodium. Recovery time was shorter with clear headedness with Propofol. There was no significant neonatal depression as assessed by Apgar score. Propofol appears to be a better alternative to Thiopentone sodium as induction agent for caesarean section.
Perspectives
The success of anaesthesia in obstetrics depends largely upon surgical demand and maternofoetal well being. Hence the aim of anaesthesia is to provide safety and comfort to the mother, minimal neonatal depression and optimal working condition for the obstetrician. Propofol 2.5 mg/kg was compared with thiopentone sodium 5mg/kg as induction agent for elective caesarean section. A total of 90 healthy pregnant patients of ASA I and II, who were scheduled for elective caesarean section were included in this study and were randomly allocated into 3 groups. Group I Thiopentone sodium 2.5% (5mg/kg), group II Propofol 0.5% (2 mg/kg) and group III Propofol 1% (2mg/kg). Induction was smooth and rapid with both Propofol and Thiopentone with minimal incidence of side effects. Induction time was found to be shortest with Propofol 1% (40.1±6.11 seconds) as compared to Thiopentone sodium 2.5% (47.2±7.26 seconds) and Propofol 0.5% (70.5±19.58 seconds). Mean arterial pressure was lower in Propofol 1% group during the induction and intraoperatively. Other hemodynamic changes were similar in all three groups. Apnoea occurred less frequently with Propofol 1% (10%) than with Thiopentone sodium (43.33%). Pain on injection (6.66%) and awareness (10%) was found with Propofol whereas cough (3.33%), hiccup (6.66%) and nausea & vomiting (33.33%) were observed with Thiopentone sodium. Recovery time was shorter with clear headedness with Propofol. There was no significant neonatal depression as assessed by Apgar score. Propofol appears to be a better alternative to Thiopentone sodium as induction agent for caesarean section.
Red Flower Publication Publications
Red Flower Publication Pvt Ltd
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This page is a summary of: A Comparative Evaluation of Thiopentone Sodium and Propofol as Inducing Agent for Caesarean Section, Indian Journal of Anaesthesia and Analgesia, January 2018, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.51118.1.
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