What is it about?
To Evaluate the Hemodynamic Effects of Induction doses of Propofol and Etomidate
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Context: Entropy monitoring enables us to administer the anaesthetic doses of induction agents with precision so as to avoid intraoperative awareness, light planes of anaesthesia on one hand and delayed recovery, haemodynamic instability on the other. Aims: To evaluate the haemodynamic effects of induction doses of propofol and etomidate under entropy guidance, in patients undergoing under general anaesthesia. Study design: A prospective, observational study. Methodology: This study was conducted on 100 patients of ASA I and II between the age group 1860 years. The patients in group A, were induced with etomidate and group B, with propofol till entropy reached a value of 40. Haemodynamic parameters at and after induction were noted. Results: All statistical calculations were done using SPSS 21 version. The mean of mean arterial pressure at 1 minute after induction in group A and B was 85.9±10 and 75.5±8 respectively (p=0.00) and after laryngoscopy, in group A and B was 98.4±8.1 and 105.3±9.1 respectively (p=0.00). Significant rise in the heart rate was seen with propofol after laryngoscopy and intubation. (p=0.018) Conclusion: On induction doses under entropy guidance, the haemodynamic effects observed with propofol were more pronounced than that of etomidate. Propofol caused more hypotension than etomidate after induction, whereas, there was statistically significant rise in heart rate after laryngoscopy and intubation.
Perspectives
Context: Entropy monitoring enables us to administer the anaesthetic doses of induction agents with precision so as to avoid intraoperative awareness, light planes of anaesthesia on one hand and delayed recovery, haemodynamic instability on the other. Aims: To evaluate the haemodynamic effects of induction doses of propofol and etomidate under entropy guidance, in patients undergoing under general anaesthesia. Study design: A prospective, observational study. Methodology: This study was conducted on 100 patients of ASA I and II between the age group 1860 years. The patients in group A, were induced with etomidate and group B, with propofol till entropy reached a value of 40. Haemodynamic parameters at and after induction were noted. Results: All statistical calculations were done using SPSS 21 version. The mean of mean arterial pressure at 1 minute after induction in group A and B was 85.9±10 and 75.5±8 respectively (p=0.00) and after laryngoscopy, in group A and B was 98.4±8.1 and 105.3±9.1 respectively (p=0.00). Significant rise in the heart rate was seen with propofol after laryngoscopy and intubation. (p=0.018) Conclusion: On induction doses under entropy guidance, the haemodynamic effects observed with propofol were more pronounced than that of etomidate. Propofol caused more hypotension than etomidate after induction, whereas, there was statistically significant rise in heart rate after laryngoscopy and intubation.
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This page is a summary of: To Evaluate the Hemodynamic Effects of Induction doses of Propofol and Etomidate under Entropy Guidance: A Prospective, Observational Study, Indian Journal of Anaesthesia and Analgesia, January 2018, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ijaa.2349.8471.51018.9.
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