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Histochemical Characteristics of Mucosubstances in Normal Human Mammary Gland
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Why is it important?
666 Mucins implicated in cancers of various organs. The apical epithelial surfaces of mammalian respiratory, gastrointestinal, and reproductive tracts are coated by mucus, a mixture of water, ions, glycoproteins, proteins, and lipids. The purpose of this study was to confirm the presence of mucin production using Haematoxylin and Eosin (H&E) stain as the gold standard and to describe the types of mucins using various types of histochemical techniques. Method: This is a retrospective, observational, analytical, case control study aimed to evaluate mucins histo-chemical pattern in normal human breast. Twenty five histologically proven normal human breast tissue were taken.Tissue sections were stained by Mayer’s Haematoxylin and Eosin, PAS, PAS-diastase, PhenylhydrazinePAS, Alcian blue 2.5, Alcian Blue 1, combined alcian blue-PAS, Aldehyde Fuschin and combined aldehyde fuchsin-alcian blue techniques. Result: The human mammary gland showed the presence of neutral mucins and acidic mucins. In acidic mucins sialomucins were present and sulfomucins were recorded in trace amount. This concludes that mucin histochemical patterns have valuable, cost-effective, and important role where a slight change in the mucin pattern may help in the early diagnosis of the disease process.
Perspectives
666 Mucins implicated in cancers of various organs. The apical epithelial surfaces of mammalian respiratory, gastrointestinal, and reproductive tracts are coated by mucus, a mixture of water, ions, glycoproteins, proteins, and lipids. The purpose of this study was to confirm the presence of mucin production using Haematoxylin and Eosin (H&E) stain as the gold standard and to describe the types of mucins using various types of histochemical techniques. Method: This is a retrospective, observational, analytical, case control study aimed to evaluate mucins histo-chemical pattern in normal human breast. Twenty five histologically proven normal human breast tissue were taken.Tissue sections were stained by Mayer’s Haematoxylin and Eosin, PAS, PAS-diastase, PhenylhydrazinePAS, Alcian blue 2.5, Alcian Blue 1, combined alcian blue-PAS, Aldehyde Fuschin and combined aldehyde fuchsin-alcian blue techniques. Result: The human mammary gland showed the presence of neutral mucins and acidic mucins. In acidic mucins sialomucins were present and sulfomucins were recorded in trace amount. This concludes that mucin histochemical patterns have valuable, cost-effective, and important role where a slight change in the mucin pattern may help in the early diagnosis of the disease process.
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This page is a summary of: Histochemical Characteristics of Mucosubstances in Normal Human Mammary Gland, Indian Journal of Anatomy, January 2018, Red Flower Publication Private, Ltd.,
DOI: 10.21088/ija.2320.0022.7318.3.
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