What is it about?
The present report consists in providing risk estimates and hazard ratios for in-hospital mortality of acute heart failure associated with acute kidney injury for the three strata of ventricular ejection fraction as recently stated by the 2016 ESC guidelines.
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Why is it important?
This applied research has the roots in the recent guidelines for the diagnosis and treatment of acute and chronic heart failure published by the European Society of Cardiology in May 2016: they defined the new category of mid-range ventricular ejection fraction, as an intermediate stratum between the heart failure with preserved and reduced ejection fraction. The American College of Cardiology Foundation/American Heart Association had already introduced the heart failure with borderline ejection fraction in 2013 and raised questions of whether it would have distinct underlying characteristics. Both professional bodies have made efforts to stimulate the research into this area and promote findings exchange.
Perspectives
The present study proved that AKI was significantly associated with higher risk of mortality in patients with HFmrEF when compared to those with HFrEF condition, thus implying a stronger AKI impact on their outcome. Larger studies are needed for exploring mechanisms and strategies to distinguish the primary origin of kidney injury in these ADHF populations and procure evidence-based therapies for them
Dr Diana Lungeanu
University of Medicine and Pharmacy Timisoara
Read the Original
This page is a summary of: Acute kidney injury: a clinical issue in hospitalized heart failure patients with mid-range ejection fraction, Polish Archives of Internal Medicine, November 2018, Towarzystwo Internistow Polskich/Polish Society of Internal Medicine,
DOI: 10.20452/pamw.4369.
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