What is it about?
The maternal THs show vital actions in the developing brain during the prenatal and postnatal periods. The maternal thyroid dysfunctions may directly or indirectly disturb the activities of ion channels, metabolic enzymes, neurotransmitter receptors, transporters, and development (morphogenesis) of the brain. This can alter the character of the nerve cells, decrease the synchronization and cause the neonatal seizure and several neurocognitive defects. Thus, the treatment can be required before the gestation to avoid these disorders. This would provide an earlier advantage to maximizing the neurological outcome. Several researches are desired to follow the impacts of maternal thyroid dysfunctions on the neonatal seizure, febrile seizure, and epilepsy before, during, and after the gestation.
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Why is it important?
The maternal thyroid dysfunctions may directly or indirectly disturb the activities of ion channels, metabolic enzymes, neurotransmitter receptors, transporters, and development (morphogenesis) of the brain. This can alter the character of the nerve cells, decrease the synchronization and cause the neonatal seizure and several neurocognitive defects.
Perspectives
The treatment can be required before the gestation to avoid these disorders. This would provide an earlier advantage to maximizing the neurological outcome.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Maternal Thyroid Disorders and Risk of Neonatal Seizure: Current Perspective, ARC Journal of Neuroscience, January 2018, ARC Publications Pvt Ltd.,
DOI: 10.20431/2456-057x.0301004.
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