Association between Maternal Omega-3-Fatty Acid and Hypothyroidism

What is it about?

The normal balance in the levels of dietary omega-3-fatty acids (anti-inflammatory actions) and maternal THs may be necessary for the normal brain development during the prenatal and postnatal periods. In addition, the deficiency in their levels during the gestation may increase the risk of teratogenic consequences and brain disorders (depression, psychotic symptoms, mental retardation, schizophrenia, Alzheimer, cognitive dysfunction, and mood disability) in fetuses, neonates, and childhood. These disturbances may increase the susceptibility of the CNS to the inflammatory-immune diseases, may decrease the neurite growth, and may inhibit the development generally. However, their developmental, molecular and biochemical mechanisms are unclear until now. The disruptions in the fetal and neonatal development may be depending on the time and severity of these deficiencies. Thus, this report can be recommended the following: (1) avoid the deficiency in levels of dietary omega-3-fatty acids and maternal THs; (2) Pregnant can keep the normal levels of dietary omega-3-fatty acids by eating the fatty fish such as salmon, tuna, and trout; (3) overconsumption of fishes should be avoided for the mercury toxicity; and (4) following the levels of maternal THs before or during pregnancy to decrease or avoid the previous disorders. Additional experiments are important to study the influence of the deficiency in levels of dietary omega-3-fatty acids and maternal THs at different stages of pregnancy (following pregnancy duration and birth dimensions) on the developing neuroendocrine system of both fetuses and neonates. The developmental, molecular, biochemical and immunological mechanisms should be examined. This could support development novel therapeutic approaches and enhance maternal and infant health consequences.

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Why is it important?

The disruptions in the fetal and neonatal development may be depending on the time and severity of the THs deficiencies. Thus, this report can be recommended the following: (1) avoid the deficiency in levels of dietary omega-3-fatty acids and maternal THs; (2) Pregnant can keep the normal levels of dietary omega-3-fatty acids by eating the fatty fish such as salmon, tuna, and trout; (3) overconsumption of fishes should be avoided for the mercury toxicity; and (4) following the levels of maternal THs before or during pregnancy to decrease or avoid the previous disorders.

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