Maternal hypothyroidism and neonatal depression: Current perspective.

What is it about?

The maternal thyroid hormones (THs) facilitate significant actions on central nervous system (CNS) during the prenatal and postnatal development and whole life. The maternal hypothyroidism and depressive symptoms are very important social health problems. In addition, the maternal hypothyroidism may cause several developmental defects and growth retardation in the fetal and neonatal central nervous system (CNS). This retardation may induce several mood disorders in particular the depression and cognitive and behavioral dysfunctions. More importantly, the neonatal depression due to the maternal hypothyroidism may cause noteworthy social and economic problems. Thus, additional research is desired not only to determine the interactions between the activities of maternal thyroid gland and developing brain in depressive disturbances but also to evaluate the genetic variations in deiodinases and neuroimaging. This strategy can assist in the treatment of depressive disorders during the development.

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Why is it important?

The maternal hypothyroidism and depressive symptoms are very important social health problems. In addition, the maternal hypothyroidism may cause several developmental defects and growth retardation in the fetal and neonatal central nervous system (CNS). This retardation may induce several mood disorders in particular the depression and cognitive and behavioral dysfunctions. More importantly, the neonatal depression due to the maternal hypothyroidism may cause noteworthy social and economic problems.

Perspectives