Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

What is it about?

Cervical cancer is staged preoperatively and the postoperative treatment depends on the combination of staging with histopathological finding. Survival is related to certain histopathological factors, most importantly lymph node status and other findings indicating that tumor may have spread i.e. parametrium and the lymph-vascular space. Other factors like tumor size and depth of stromal invasion indicate aggressive biological behavior. Poorer survival depending on histological type of tumor is reported in adenocarcinoma compared to squamous carcinoma (1-7). The concurrent increasing incidence of adenocarcinoma associated with use of oral contraceptives in the Western World is a concern to that it may reverse the positive effect of screening (6,7). However, the survival relates heavily on different pre- and postoperative treatment regimens and stage of disease (1,3,4). Adverse histopathological factors are often present simultaneously and reviewed heterogeneously. The aim of our study was to evaluate independent histopathological factors for women with radical hysterectomy with focus on standardized histopathological diagnosis combined with similar pre- and postoperative treatment.

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