What is it about?
To understand how CoQ0 can potentially be used as chemopreventive agent by modulating the Wnt/β-catenin signaling pathway in melanoma cells. The finding shows that the efficacy of CoQ0 in cell growth inhibition and induction of apoptosis is likely due to the suppression of the Wnt/β-catenin signalling pathway in melanoma cells
Featured Image
Why is it important?
The finding highlights the importance of Wnt/β-catenin and their transcriptional targets that can serve as the future targets for the development of therapeutic strategies against human melanoma
Perspectives
This is likely the first report that indicates the in vitro and in vivo anti-cancer potential of CoQ0 against malignant melanoma. Learning the novel mechanism by down-regulating Wnt/β-catenin signalling pathway in melanoma cells could encourage for more options for the future melanoma chemotherapy. This is another evidence on the anticancer properties of CoQ0, a key ingredient in Antrodia camphorata, a unique mushroom of Taiwan
Dr. You-cheng Hseu
China Medical University
Read the Original
This page is a summary of: In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways, Oncotarget, March 2016, Impact Journals, LLC,
DOI: 10.18632/oncotarget.7983.
You can read the full text:
Resources
Contributors
The following have contributed to this page
