What is it about?
The lateralisation of ictal EEG is mainly based on the first appearance and amplitude difference between the two hemispheres at seizure onset. On the other hand, a number of ictal propagation patterns (iPP) may occur throughout the progressing seizure, such as "switch-of lateralisation" and "bilateral asynchrony" observed on scalp EEG of patients with temporal lobe epilepsy. However, the pathophysiology of switch-of lateralisation and bilateral temporal asynchrony in temporal lobe epilepsy is poorly understood. In this study, we aimed to investigate inter-hemispheric functional connectivity changes of the temporal lobe and related areas in patients with temporal lobe epilepsy with iPP and without iPP.
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Why is it important?
Our findings revealed that functional connectivities between homologous temporal lobe regions are reduced in patients with temporal lobe epilepsy compared to healthy individuals. Furthermore, switch-of lateralisation and bilateral asynchrony may be related with reduced functional connectivity between homologous insulae and may play a role in the pathophysiology of this unusual pattern.
Perspectives
The precise mechanism underlying these atypical and rare seizure propagation patterns needs to be elucidated in future studies.
Cigdem Ulasoglu-Yildiz
Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University
Read the Original
This page is a summary of: Functional connectivity analysis of patients with temporal lobe epilepsy displaying different ictal propagation patterns*, Epileptic Disorders, October 2020, Wiley,
DOI: 10.1684/epd.2020.1210.
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