What is it about?
Acute kidney injury (AKI) is a common clinical condition associated with high morbidity and mortality. However, the mechanisms that determine the renal prognosis after AKI have remained unclear. Adenosine 5’ triphosphate (ATP) is often referred to as the "molecular unit of currency" of intracellular energy transfer, because of its key roles in energy metabolism. The kidney constantly requires a large amount of ATP to reabsorb solutes such as sugars, amino acids and electrolytes. We succeeded in visualizing ATP dynamics during AKI at a single cell resolution. Furthermore, we found that the ATP recovery of proximal tubules after AKI might predict renal prognosis.
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Photo by Robina Weermeijer on Unsplash
Why is it important?
This revolutionary ATP imaging technique improves our understanding of the cellular events in the diseased kidney. Therefore, our ATP visualization technique could be a useful tool to develop targeted therapies, screen drug efficacy and assess drug toxicity.
Perspectives
This ATP imaging tool is extremely useful for visualizing energy dynamics in vivo at a single cell level. We are working on the visualization of energy metabolism in various pathophysiological conditions using this mouse. We would also like to take this opportunity to sincerely thank our collaborators in this study.
Motoko Yanagita
Read the Original
This page is a summary of: Spatiotemporal ATP Dynamics during AKI Predict Renal Prognosis, Journal of the American Society of Nephrology, October 2020, American Society of Nephrology,
DOI: 10.1681/asn.2020050580.
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