Prevent BKV-associated nephropathy

What is it about?

BK virus-associated nephropathy is one of the major causes of graft dysfunction and loss in kidney transplantation.The role of the humoral immune response in control of BKV infection has been a long-standing puzzle. This paper examines the impact of BKV neutralizing antibody titers on BKV infection occurence in kidney transplant recipients.

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Why is it important?

We have demonstrated for the first time that BKV neutralizing antibodies can protect against BKV infection. We identified a cutoff value that allows patient stratification into lower and higher BKV disease risk groups at the time of transplantation. This finding offers a useful tool for clinicians to improve kidney transplant management and pave the way for the development of new preventive or therapeutic strategies.

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