What is it about?
Infections caused by antibiotic-resistant bacteria, such as MRSA, vancomycin-resistant enterococci, carbapenem-resistant Pseudomonas, ESBL-producing E. coli and Klebsiella, and multidrug-resistant Acinetobacter, have increased dramatically, particularly in intensive care units. Few effective antibiotics remain against them. In this review we discuss what clinicians can do: reduce patients' exposure to antibiotics, avoid unnecessary treatments, shorten therapy when possible and choose drugs and doses wisely, alongside infection control measures.
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Why is it important?
Clinicians' prescribing choices directly shape resistance in their units. This review offers practical strategies to treat critically ill patients effectively while reducing the selective pressure that drives resistance.
Perspectives
This early review with Nicola Petrosillo shaped my view of antimicrobial stewardship: every prescription matters, and the best way to preserve antibiotics for tomorrow is to use them wisely today.
Professor Stefano Di Bella
Universita degli Studi di Trieste
Read the Original
This page is a summary of: Management of antibiotic resistance in the intensive care unit setting, Expert Review of Anti-infective Therapy, March 2010, Taylor & Francis,
DOI: 10.1586/eri.10.7.
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