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The new model for evaluating the viability of a tissue engineering implant during critical airway defect closure was obtained. Two-layer vitalization of DTS with lung epithelial cells and BM-MSCs allows creating a tissue-engineered structure for replacement of non-long tracheal defects in the experiment in vivo. The use of the tracheal tissue-engineered graft for orthotopic implantation showed biocompatibility with minimal tissue reaction.
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This page is a summary of: Experimental orthotopic implantation of tissue-engineered tracheal graft created based on devitalized scaffold seeded with mesenchymal and epithelial cells, Russian Journal of Transplantology and Artificial Organs, February 2020, V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs,
DOI: 10.15825/1995-1191-2019-4-96-107.
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