The Effect of Biological Clock & Molecular Clock in Cancer

What is it about?

Nowadays change in lifestyle can most effect in our health, such as Insomnia & circadian rhythm changes. In this mini-review article, we focus on the circadian rhythm changes and cancer. Our study was shown to us, existence any changes in the circadian rhythm and biological clock leads to various changes in the levels of melatonin in the human body. Melatonin in Human cells, it is responsible for the adjustment of the circadian rhythm and produced in pineal glands. Disruption in levels of melatonin definitely related to cancers, such as ovary, uterus, prostate, endometrium, leukemia, breast cancer. Circadian rhythm controlled by 8 important and mainly genes that related to apoptosis, cell cycle, and checkpoint. Changes in this genes significantly related to cancers. Finally, these results are obtained that the change in the biological clock, causing a change in the molecular clock. Following the regular sleep pattern, a major role in human health.

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Why is it important?

Prevention is always better than treatment. In this review article, by studying the regular and apparently simple incidences that happens in our body routinely and adjusting the circadian rhythm and investigating their relation to cancer development, we have tried to simply provide a way to prevent cancer.