What is it about?
Accumulation of oral cancer incidence among non-smoker, non-drinker elderly female patients is conspicuous. Structures of upper aerodigestive tract are moderately estrogen dependent; they are endangered by cancer development only in case of deep estrogen deficiency. By contrast, female reproductive organs have high estrogen demand and even a mild defect of estrogen surveillance may be cancer risk factor for them.
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Why is it important?
Controversial results on the carcinogenic capacity of estrogen derive from the misinterpretation of the importance of estrogen signaling in cancer prevention.
Perspectives
Cellular estrogen surveillance may be regarded as strong defense against cancer initiation and progression. Cancer prevention and treatment may be performed by exogenous estrogen treatment or by developing new estrogen sensitizing drugs.
professor Zsuzsanna Suba
National Institute of Oncology Budapest
Read the Original
This page is a summary of: Carcinogenesis theory based on estrogen deficiency, Orvosi Hetilap, June 2009, Akademiai Kiado,
DOI: 10.1556/oh.2009.28646.
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