What is it about?
The aim of the study was to determine a role of elevated endometrial synthesis of prostaglandin F2α (PGF2α) and its high amounts in the uterine lumen during embryo implantation period.
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Why is it important?
In the present study we have determined a novel role of prostaglandin F2α as an embryonic signal mediator in the uterine endometrium using in vivo and in vitro models. Our study indicates that PGF2α acting through its receptor in the endometrium and embryo promotes angiogenesis and regulates expression of genes involved in embryo-maternal communication and endometrial remodeling.
Perspectives
Our findings indicate a novel role for eicosanoid PGF2α – a molecule which has been considered as rather an undesired factor in the early pregnancy since its administration can terminate pregnancy. On the other hand, elevated amounts of PGF2α in the uterine lumen and/or its endometrial synthesis are observed during the implantation period in various mammals with different types of placentation. Present study gives a new insight into role of PGF2α in the embryo implantation period, which involves, among other things, promoting angiogenesis process.
Dr. Agnieszka Waclawik
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences
Read the Original
This page is a summary of: Prostaglandin F2α promotes angiogenesis and embryo–maternal interactions during implantation, Reproduction, February 2016, Bioscientifica,
DOI: 10.1530/rep-15-0496.
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