NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice

What is it about?

Nicotinamide Nucleotide Transhydrogenase (NNT) is an ubiquitous antioxidant enzyme that provides mitochondrial NADPH required for reactive oxygen species (ROS) detoxification. NNT loss has previously been associated with abnormalities in insulin metabolism in mice, and recently we have described biallelic mutations in humans causing Familial Glucocorticoid Deficiency, an adrenal specific disease in which patients fail to produce glucocorticoids. In this paper we investigate the role of NNT in the mouse adrenal and by using in vivo models reveal that under or over expression of NNT disturbs adrenal redox homeostasis and reduces corticosterone output implying a central role for it in the control of steroidogenesis.

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