Tissue thyroid hormone metabolism is differentially regulated during illness in mice

What is it about?

. Illness induces a variety of changes in in the hypothalamus-pituitary-thyroid axis, so-called non-thyroidal illness syndrome. One of the hallmarks of NTIS is a profound change in peripheral thyroid hormone metabolism resulting in organ specific changes in local thyroid hormone availability depending on type and severity of illness. Local thyroid hormone availability is of importance for the regulation of the tissue specific thyroid hormone target genes. In the present study we evaluated changes in thyroid hormone transport, deiodination, and thyroid hormone receptor expression, the resulting tissue thyroid hormone concentrations and the expression of thyroid hormone target genes in liver and muscle in three animal models of illness.

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