Decrease in Ins+Glut2LO β-cells with advancing age in mouse and human pancreas

What is it about?

Examination of the mouse and human pancreas throughout the entire lifespan demonstrates that endocrine pancreas progenitor cells, as defined by the presence of insulin but which lack Glut2, are preferentially located outside of islets in small beta cell clusters. These cells decrease with age in both species, and strikingly in the human at puberty, concomitant with a decrease in cluster proportion and pancreas maturation. These cells are further implicated during endocrine regeneration following beta cell ablation in the neonatal mouse.

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