Distinct pathways of cholesterol biosynthesis impact on insulin secretion

What is it about?

This manuscript shows the importance of cholesterol and molecules derived from cholesterol biosynthesis in the insulin secretion process.

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Why is it important?

In our work we used simvastatin, widely used drug for the reduction of plasmatic cholesterol levels. However, our results shown the negative effects that cholesterol and its intermediates reduction have for pancreatic beta cell physiology and consequently glycemic control.

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