Growth hormone releasing hormone is abnormally elevated in patients with X-linked acrogigantism

What is it about?

This study shows for the first time that GHRH levels are chronically elevated in patients with X-linked acrogigantism syndrome and that stimulation and blockade of GHRH receptors in tumor cells can alter growth hormone and prolactin secretion

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Why is it important?

This supports the concept that X chromosome duplications in X-linked acrogigantism involving GPR101 are associated with elevated GHRHR secretion and this secretion plays a role in pituitary hyperplasia and tumorigenesis.