What is it about?
Using hyperlipidemia mice, we show that Lactobacillus cocktail has different effects on the intestinal microflora compared to pharmaceutical drugs such as Simvastatin. We also show the reduced levels of cholesterolemia and weight in hyperlipidemia mice treated with Lactobacillus as well as beneficial effects on LDL/HDL ratio, neutral lipid accumulation, cholesterol removal and antioxidant activities.
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Why is it important?
Our Lactobacillus cocktail is found to act on the gut flora in order to have both curative and preventive effects on the accumulation of lipids in the blood and fat in various organ tissues of the digestive tract of mice. What effects the cocktail has in human or in animals of industrial interests needs to be investigated with caution. It could help digestion and thereby reproduction in mammals (improve milk and meat industry). Applied to human health, it could have very beneficial effects in patients suffering lipid metabolism pathology and/or Simvastatin therapy.
Perspectives
We propose a new probiotic with important considerations for human health. The optimized formulation of our Lactobacillus cocktail could be extremely beneficial not only to eliminate the secondary effects due to chemical drugs such as Simvastatin, but also to put on the brakes the development of pathological conditions from cancer to diabetes and obesity.
Prof. Dr. Jean-François Jeff Picimbon
Qilu University of Technology
Read the Original
This page is a summary of: A Lactobacillus Cocktail Changes Gut Flora and Reduces Cholesterolemia and Weight Gain in Hyperlipidemia Mice, SOJ Microbiology & Infectious Diseases, January 2014, Symbiosis Group,
DOI: 10.15226/sojmid.2014.00119.
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