What is it about?
This article explains how drug-induced lupus is both similar to and different from "real" lupus and different from other side-effects of various medications.
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Why is it important?
Drug-induced lupus offers a window into how autoimmunity is normally prevented and how reactive compounds can disrupt immune tolerance to self.
Perspectives
It is argued that disruption of central T cell tolerance as T cells undergo selection in the thymus is a fundamental vulnerability of the adaptive immune system and may underlie idiopathic autoimmune diseases as well.
Professor Robert L Rubin
University of New Mexico
Read the Original
This page is a summary of: Drug-induced lupus, Expert Opinion on Drug Safety, January 2015, Informa Healthcare,
DOI: 10.1517/14740338.2015.995089.
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